Endocytosis and cancer: an 'insider' network with dangerous liaisons.

@article{Lanzetti2008EndocytosisAC,
  title={Endocytosis and cancer: an 'insider' network with dangerous liaisons.},
  author={Letizia Lanzetti and Pier Paolo Di Fiore},
  journal={Traffic},
  year={2008},
  volume={9 12},
  pages={2011-21}
}
From the signaling point of view, endocytosis has long been regarded as a major mechanism of attenuation, through the degradation of signaling receptors and, in some cases, of their ligands. This outlook has changed, over the past decade, as it has become clear that signaling persists in the endocytic route, and that intracellular endocytic stations (the 'signaling endosomes') actually contribute to the sorting of signals in space and time. Endocytosis-mediated recycling of receptors and of… CONTINUE READING

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