Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.

  title={Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.},
  author={Adrian E. Morelli and Adriana T. Larregina and William J. Shufesky and Mara L. G. Sullivan and Donna Beer Stolz and Glenn D. Papworth and Alan F. Zahorchak and Alison J. Logar and Zhiliang Wang and Simon C Watkins and Louis D. Falo and Angus W. Thomson},
  volume={104 10},
Exosomes are nanovesicles released by leukocytes and epithelial cells. Although their function remains enigmatic, exosomes are a source of antigen and transfer functional major histocompatibility complex (MHC)-I/peptide complexes to dendritic cells (DCs) for CD8(+) T-cell activation. Here we demonstrate that exosomes also are internalized and processed by immature DCs for presentation to CD4(+) T cells. Endocytosed exosomes are sorted into the endocytic compartment of DCs for processing… 

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