Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1.

@article{Skarpen1998EndocytosedEG,
  title={Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1.},
  author={Ellen Skarpen and Lene E. Johannessen and K Bjerk and H Fasteng and Tormod K Guren and Birgitte Lindeman and Gunn Hege Thoresen and Thoralf Christoffersen and Espen Stang and Henrik Sverre Huitfeldt and Inger Helene Madshus},
  journal={Experimental cell research},
  year={1998},
  volume={243 1},
  pages={
          161-72
        }
}
We investigated the ability of endocytosed activated epidermal growth factor receptors (EGFR) to induce expression of the cyclin-interacting protein p21/CIP1 in A431 cells. Transforming growth factor alpha (TGFalpha) and EGF both induced tyrosine phosphorylation, induction of p21/CIP1, and thereby inhibition of DNA synthesis. TGFalpha is released from the EGFR when the TGFalpha-EGFR complex encounters low pH upon endocytosis. Consistently, we found more rapid dephosphorylation of the EGFR and… CONTINUE READING
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