Endocytic trafficking of activated EGFR is AP-2 dependent and occurs through preformed clathrin spots.

@article{Rappoport2009EndocyticTO,
  title={Endocytic trafficking of activated EGFR is AP-2 dependent and occurs through preformed clathrin spots.},
  author={Joshua Z. Rappoport and Sanford M Simon},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 9},
  pages={1301-5}
}
The removal of the epidermal growth factor receptor (EGFR) from the cell surface by endocytosis is triggered by receptor activation, but many facets of EGFR trafficking remain unresolved. We employed total internal fluorescence microscopy to elucidate the dynamics of activated EGFR at the cell surface through live-cell imaging. The results of these studies demonstrate that: (1) EGFR does not localize to caveolae in live cells either before or after activation; (2) EGFR does localize to clathrin… CONTINUE READING