Endocytic sites mature by continuous bending and remodeling of the clathrin coat

@article{Avinoam2015EndocyticSM,
  title={Endocytic sites mature by continuous bending and remodeling of the clathrin coat},
  author={Ori Avinoam and Martin Schorb and Carsten J{\"o}rn Beese and John A. G. Briggs and Marko Kaksonen},
  journal={Science},
  year={2015},
  volume={348},
  pages={1369-1372}
}
During clathrin-mediated endocytosis (CME), plasma membrane regions are internalized to retrieve extracellular molecules and cell surface components. Whether endocytosis occurs by direct clathrin assembly into curved lattices on the budding vesicle or by initial recruitment to flat membranes and subsequent reshaping has been controversial. To distinguish between these models, we combined fluorescence microscopy and electron tomography to locate endocytic sites and to determine their coat and… CONTINUE READING
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