Endocytic regulation of Notch signaling.

Abstract

Endocytosis and endosomal trafficking have emerged as important cell biological steps in the Notch developmental signaling pathway. Ligand endocytosis helps generate the physical forces needed to dissociate and activate the receptor, and activated receptors enter endosomes to signal productively. Endosomal trafficking is also responsible for downregulating… (More)
DOI: 10.1016/j.gde.2009.04.005

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Cite this paper

@article{Fortini2009EndocyticRO, title={Endocytic regulation of Notch signaling.}, author={Mark E. Fortini and David Bilder}, journal={Current opinion in genetics & development}, year={2009}, volume={19 4}, pages={323-8} }