Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration.

@article{Cao2006EndocyticRL,
  title={Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration.},
  author={Chunzhang Cao and Daniel A Lawrence and Yang Li and Christine A. F. von Arnim and Joachim Herz and Enming Joseph Su and Alexandra Makarova and Bradley T. Hyman and Dudley K Strickland and Li Zhang},
  journal={The EMBO journal},
  year={2006},
  volume={25 9},
  pages={1860-70}
}
Migration of activated macrophages is essential for resolution of acute inflammation and the initiation of adaptive immunity. Here, we show that efficient macrophage migration in inflammatory environment depends on Mac-1 recognition of a binary complex consisting of fibrin within the provisional matrix and the protease tPA (tissue-type plasminogen activator). Subsequent neutralization of tPA by its inhibitor PAI-1 enhances binding of the integrin-protease-inhibitor complex to the endocytic… CONTINUE READING

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