Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity.

Abstract

Immune responses are initiated when molecules of microbial origin are sensed by the Toll-like receptors (TLRs). We now report the identification of essential molecular components for the trafficking of the lipopolysaccharide (LPS) receptor complex. LPS was endocytosed by a receptor-mediated mechanism dependent on dynamin and clathrin and colocalized with… (More)

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@article{Husebye2006EndocyticPR, title={Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity.}, author={Harald Husebye and \Oyvind Halaas and Harald Stenmark and Gro Tunheim and \Oystein Sandanger and Bjarne Bogen and Andreas Brech and Eicke Latz and Terje Espevik}, journal={The EMBO journal}, year={2006}, volume={25 4}, pages={683-92} }