Endocytic mechanism of transferrin-conjugated nanoparticles and the effects of their size and ligand number on the efficiency of drug delivery.

@article{Tsuji2013EndocyticMO,
  title={Endocytic mechanism of transferrin-conjugated nanoparticles and the effects of their size and ligand number on the efficiency of drug delivery.},
  author={Takuma Tsuji and Hiroshi Yoshitomi and Jiro Usukura},
  journal={Microscopy},
  year={2013},
  volume={62 3},
  pages={341-52}
}
When considering drug delivery, the amount of drug that can be carried at a particular time and how the drug is incorporated efficiently into cells are important parameters. Transferrin (Tf)-conjugated nanocarriers have been used for the targeted delivery of drugs to cancer cells due to the availability of receptor-mediated clathrin-dependent endocytosis. In general, however, endocytosis seems to differ according to the size and shape of carriers. Large substances are generally internalized… CONTINUE READING