Endocytic deficiency induced by ITSN-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5

@inproceedings{Bardita2015EndocyticDI,
  title={Endocytic deficiency induced by ITSN-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5},
  author={Cristina Bardita and Dan N. Predescu and Fei Sha and Monal Patel and Ganesh Balaji and Sanda A. Predescu},
  booktitle={Journal of cell science},
  year={2015}
}
Recently, we demonstrated in cultured endothelial cells and in vivo that deficiency of an isoform of intersectin-1, ITSN-1s, impairs caveolae and clathrin-mediated endocytosis and functionally upregulates compensatory pathways and their morphological carriers (i.e. enlarged endocytic structures, membranous rings or tubules) that are normally… CONTINUE READING