Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles

@article{Dobrowolski2011EndocyticCO,
  title={Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles},
  author={Radek Dobrowolski and Edward M. De Robertis},
  journal={Nature Reviews Molecular Cell Biology},
  year={2011},
  volume={13},
  pages={53-60}
}
Signal transduction and endocytosis are intertwined processes. The internalization of ligand-activated receptors by endocytosis has classically been thought to attenuate signals by targeting receptors for degradation in lysosomes, but it can also maintain signals in early signalling endosomes. In both cases, localization to multivesicular endosomesen route to lysosomes is thought to terminate signalling. However, during WNT signal transduction, sequestration of the enzyme glycogen synthase… CONTINUE READING
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