Endocytic Trafficking of Integrins in Cell Migration

@article{Paul2015EndocyticTO,
  title={Endocytic Trafficking of Integrins in Cell Migration},
  author={Nikki R. Paul and Guillaume Jacquemet and Patrick T. Caswell},
  journal={Current Biology},
  year={2015},
  volume={25},
  pages={R1092-R1105}
}
Integrins are a family of heterodimeric receptors that bind to components of the extracellular matrix and influence cellular processes as varied as proliferation and migration. These effects are achieved by tight spatiotemporal control over intracellular signalling pathways, including those that mediate cytoskeletal reorganisation. The ability of integrins to bind to ligands is governed by integrin conformation, or activity, and this is widely acknowledged to be an important route to the… CONTINUE READING
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