Endocytic Delivery to Lysosomes Mediated by Concurrent Fusion and Kissing Events in Living Cells

@article{Bright2005EndocyticDT,
  title={Endocytic Delivery to Lysosomes Mediated by Concurrent Fusion and Kissing Events in Living Cells},
  author={Nicholas A. Bright and Matthew J. Gratian and J. Luzio},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={360-365}
}
In mammalian cells, macromolecules internalized by endocytosis are transported via endosomes for digestion by lysosomal acid hydrolases . The mechanism by which endosomes and lysosomes exchange content remains equivocal . However, lysosomes are reusable organelles because they remain accessible to endocytic enzyme replacement therapies and undergo content mixing with late endosomes . The maturation model, which proposes that endosomes mature into lysosomes , cannot explain these observations… CONTINUE READING
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