Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

  title={Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer},
  author={Jae Myoung Suh and Johan W. Jonker and Maryam Ahmadian and Regina M Goetz and Denise E. Lackey and Olivia Osborn and Zifeng Huang and Weilin Liu and Eiji Yoshihara and Theo H. van Dijk and Rick Havinga and Weiwei Fan and Yun-qiang Yin and Ruth T Yu and Christopher Liddle and Annette R. Atkins and Jerrold M. Olefsky and Moosa Mohammadi and Michael Downes and Ronald M Evans},
Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation. Although FGF1 is known as a mitogenic factor, FGF1 knockout mice develop insulin resistance when stressed by a high-fat diet, suggesting a potential role in nutrient homeostasis. Here we show that parenteral delivery of a single dose of recombinant FGF1 (rFGF1) results in potent, insulin-dependent lowering of glucose levels in diabetic mice… CONTINUE READING
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