Endocrine treatment of transsexual persons: an Endocrine Society Clinical Practice Guideline: commentary from a European perspective.

@article{Meriggiola2010EndocrineTO,
  title={Endocrine treatment of transsexual persons: an Endocrine Society Clinical Practice Guideline: commentary from a European perspective.},
  author={Maria Cristina Meriggiola and Emmanuele Angelo Jannini and Andrea Lenzi and Mario Maggi and Chiara Manieri},
  journal={European journal of endocrinology},
  year={2010},
  volume={162 5},
  pages={
          831-3
        }
}
The treatment of transsexual subjects is a challenging task for the endocrinologist who, in collaboration with the mental health professional and the surgeon, is called upon to confirm the diagnosis and adjust hormonal treatment aimed at suppressing endogenous sex hormones and to develop hormone characteristics of the desired gender. These guidelines are structured to provide evidence-based suggestions or, where evidence is lacking, expert recommendations on diagnostic procedures and hormonal… 

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Effects of three different testosterone formulations in female-to-male transsexual persons.

One-year testosterone administration in FtM transsexuals appears to be very safe with no differences among the testosterone formulations used and the detection of subtle or long-term differences in the effects of the three formulations may require further larger and longer term studies in this and other populations.

Endocrine care of transpeople part II. A review of cross‐sex hormonal treatments, outcomes and adverse effects in transwomen

The treatment of transwomen relies on the combined administration of anti‐androgens or GnRH analogues to suppress androgen production and thereby reduce male phenotypic characteristics together with oestrogens to develop female characteristics and long‐term monitoring should aim to decrease cardiovascular risks.

The Female-to-Male Medical Treatment

Transsexualism refers to a condition where an individual identifies with a gender that differs from the assigned sex, and treatments need to be customized, as some individuals need cross-sex hormone therapy and surgery to alleviate their gender dysphoria.

Sociodemographic characteristics and traumatic experiences in an Italian transgender sample

The authors' data showed that participants who had experienced traumatic events sought assistance at an older age, had a lower level of education and a higher rate of unemployment, and had taken cross-sex hormonal therapy without a doctor's prescription at a higher frequency than those without experience of traumatic events.

References

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Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline.

This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe the strength of recommendations and the quality of evidence, which was low or very low.

Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience.

Cross-sex hormone treatment of transsexuals seems acceptably safe over the short and medium term, but solid clinical data are lacking.

Surgical Therapy in Transsexual Patients: a Multi-Disciplinary Approach

The results in this series of patients clearly demonstrate that a close cooperation of the different surgical specialties, within the authors' multidisciplinary gender team, is the key to success in treating transsexual patients.

Hormone-related tumors in transsexuals receiving treatment with cross-sex hormones.

The probability of a hormone-related tumor increases with the duration of exposure to cross-sex hormones and the aging of the population of transsexuals, so far only a few cases of hormone- related cancer in transsexuals are encountered.

Effect of long-term testosterone administration on the endometrium of female-to-male (FtM) transsexuals.

The data suggest that exogenous T administration does not stimulate endometrial proliferation in FtM transsexuals and indeed may have atrophic effects.

ORIGINAL RESEARCH—INTERSEX AND GENDER IDENTITY DISORDERS The Treatment of Adolescent Transsexuals: Changing Insights

Treatment of individuals with gender identity disorder (GID) has in medicine nearly always met with a great deal of skepticism.

Sex reassignment: outcomes and predictors of treatment for adolescent and adult transsexuals.

The results substantiate previous conclusions that sex reassignment is effective and clinicians need to be alert for non-homosexual male-to-females with unfavourable psychological functioning and physical appearance and inconsistent gender dysphoria reports, as these are risk factors for dropping out and poor post-operative results.

Venous thrombosis and changes of hemostatic variables during cross-sex hormone treatment in transsexual people.

The large differential effect of oral EE and oral E(2) indicates that the prothrombotic effect of EE is due to its molecular structure rather than to a first-pass liver effect (which they share).

Total Laparoscopic Hysterectomy for Female-to-Male Transsexuals

Total laparoscopic hysterectomy offers appropriate surgical outcomes for those patients identifying themselves as transsexual with those of female patients.