Endocrine therapy resistance in estrogen receptor (ER)-positive breast cancer.

  title={Endocrine therapy resistance in estrogen receptor (ER)-positive breast cancer.},
  author={Tommaso De Marchi and John A. Foekens and Arzu Umar and John W. M. Martens},
  journal={Drug discovery today},
  volume={21 7},
Estrogen receptor (ER)-positive breast cancer represents the majority (∼70%) of all breast malignancies. In this subgroup of breast cancers, endocrine therapies are effective both in the adjuvant and recurrent settings, although resistance remains a major issue. Several high-throughput approaches have been used to elucidate mechanisms of resistance and to derive potential predictive markers or alternative therapies. In this review, we cover the state-of-the-art of endocrine-resistance biomarker… CONTINUE READING
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