Endocrine side-effects of anti-cancer drugs: the impact of retinoids on the thyroid axis.

@article{GraeppiDulac2014EndocrineSO,
  title={Endocrine side-effects of anti-cancer drugs: the impact of retinoids on the thyroid axis.},
  author={Julia Graeppi-Dulac and Virginie Vlaeminck-Guillem and Marie Perier-Muzet and St{\'e}phane Dalle and Jacques Orgiazzi},
  journal={European journal of endocrinology},
  year={2014},
  volume={170 6},
  pages={R253-62}
}
Bexarotene (Targretin), approved since 1999 as a second-line treatment for late stage cutaneous T-cell lymphomas, has been shown to induce significant hypothyroidism through TSH suppression. This review revisits, through a case report, mechanisms by which rexinoids repress the expression of TSHB gene as well as αTSH and TRH genes. It appears that rexinoids suppress TSH independently from tri-iodothyronine. Bexarotene also differently affects the gene expression of deiodinases 1 and 2 as well as… CONTINUE READING

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