Endocrine resistance in breast cancer--An overview and update.

  title={Endocrine resistance in breast cancer--An overview and update.},
  author={Robert Clarke and John J. Tyson and J Michael J Dixon},
  journal={Molecular and cellular endocrinology},
  volume={418 Pt 3},
Tumors that express detectable levels of the product of the ESR1 gene (estrogen receptor-α; ERα) represent the single largest molecular subtype of breast cancer. More women eventually die from ERα+ breast cancer than from either HER2+ disease (almost half of which also express ERα) and/or from triple negative breast cancer (ERα-negative, progesterone receptor-negative, and HER2-negative). Antiestrogens and aromatase inhibitors are largely indistinguishable from each other in their abilities to… CONTINUE READING
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