Endocrine regulation of the course of menopause by oral melatonin: first case report

@article{Daz2008EndocrineRO,
  title={Endocrine regulation of the course of menopause by oral melatonin: first case report},
  author={Beatriz Dı́az and Placido Llaneza},
  journal={Menopause},
  year={2008},
  volume={15},
  pages={388-392}
}
Objective: The pineal gland, through its hormone melatonin, is involved in the mechanisms that regulate the aging process involved in the onset of menopause. Considering the melatonin changes reported during pre-, peri-, and postmenopause, an influence of melatonin on the hormonal changes associated with menopause transition could be expected. Design: We report the first longitudinal case study, covering a 7.5-year period, on the effects of melatonin administration on the reproductive hormones… 
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Role of Pineal Hormone Melatonin in a Woman’s Life: From Conception to Decline of Life
TLDR
Focus is given to melatonin effect on the female reproductive system, its participation in the aging process, and formation of pathological menopause, and research data on the effectiveness of the melatonin drug when tackling climacteric syndrome is presented.
The Effect of Melatonin on Climacteric Symptoms in Menopausal Women; A Double-Blind, Randomized Controlled, Clinical Trial
TLDR
The study findings showed that using melatonin improved the climacteric symptoms in postmenopausal women.
The impact of factors in work environment (especially shift and night work) on neoplasia of female reproductive organs
TLDR
This work describes and discusses pathophysiology, epidemiological and clinical data concerning influence of shift work to occurrence of some neoplasms and the association between disruption in melatonin secretion and the occurrence of certain malignancies.
Alternative Options to Manage Menopausal Symptoms with a Focus on Melatonin and Osteoporosis
TLDR
The focus of this mini-review is to highlight the novel use of melatonin on managing menopausal symptoms and menopausal bone loss and describe food sources that are rich in melatonin.
Plasma melatonin circadian rhythm disturbances during pregnancy and postpartum in depressed women and women with personal or family histories of depression.
TLDR
Plasma nocturnal melatonin concentrations, particularly during morning hours, were lower in depressed pregnant women but elevated in depressed postpartum women relative to matched healthy comparison women, implicate disturbances in the regulation of the melatonin generating system in pregnancy and post partum depression.
Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair
TLDR
An update of the relevant cutaneous effects and mechanisms of melatonin, portray melatonin as a major skin protectant and sketch how its multi‐facetted functions may impact on skin biology and pathology are illustrated.
Melatonin osteoporosis prevention study (MOPS): a randomized, double‐blind, placebo‐controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women
TLDR
Findings show that melatonin supplementation was well tolerated, improved physical symptoms associated with perimenopause, and may restore imbalances in bone remodeling to prevent bone loss.
Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats
TLDR
Results indicated that 17β-oestradiol and melatonin treatments were able to significantly decrease expression of pro-inflammatory cytokines, iNOS and HO-1 in the hippocampus when compared to non-treated animals, which support the potential therapeutic role of melatonin and oestradio as protective anti-inflammatory agents for the central nervous system during menopause.
Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints.
TLDR
Emerging pharmacological evidence supports a role for V. agnus-castus in the alleviation of menopausal symptoms and suggests that further investigation may be appropriate.
Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.
TLDR
Despite some methodological limitations, the results from randomised, controlled trials to date suggest benefits for Vitex extracts in the treatment of pre menstrual syndrome, premenstrual dysphoric disorder and latent hyperprolactinaemia.
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