Endocrine profile of topterone, a topical antiandrogen, in three species of laboratory animals.

@article{Ferrari1980EndocrinePO,
  title={Endocrine profile of topterone, a topical antiandrogen, in three species of laboratory animals.},
  author={Roseli Ap. Ferrari and Kaveri Chakrabarty and John E. Creange and Arthur L. Beyler and O G Potts and H. Philip Schane},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1980},
  volume={2 2},
  pages={
          65-9
        }
}
Topterone, 17 alpha-propyltestosterone, was administered parenterally or topically to rats, rabbits or hamsters to determine its endocrine profile. Systemic administration demonstrated that topterone was both antiandrogenic and progestational. Topical application failed to elicit a systemic antiandrogenic response at 1 g/kg/day and only a minimal progestational response was seen at 32 mg/kg/day. No other endocrine activities were detected. 

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