Endocrine pancreas development in growth-retarded human fetuses.

@article{Bringue2002EndocrinePD,
  title={Endocrine pancreas development in growth-retarded human fetuses.},
  author={Fr{\'e}d{\'e}rique B{\'e}ringue and Bertrand Blondeau and Marie Claire Castellotti and B. Breant and Paul C Czernichow and Michel Polak},
  journal={Diabetes},
  year={2002},
  volume={51 2},
  pages={
          385-91
        }
}
Glucose intolerance in adults born with intrauterine growth retardation (IUGR) may involve peripheral insulin resistance and/or abnormal endocrine pancreas development during fetal life. We quantified insulin-containing cells in deceased human fetuses with IUGR (<10th percentile, n = 21) or normal growth (control fetuses, n = 15). Paraffin-embedded pancreatic tissues from fetuses older than 32 weeks were obtained from two fetopathology departments. Mean gestational age was 36 weeks in both… CONTINUE READING

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