Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial.

@article{Laughton2008EndocrineOF,
  title={Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial.},
  author={Stephen J Laughton and Thomas E. Merchant and Charles A. Sklar and Larry E. Kun and Maryam Fouladi and Alberto Broniscer and E. Brannon Morris and Robert P. Sanders and Matthew J. Krasin and John Shelso and Zang Xiong and Dana J. Wallace and Amar Gajjar},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2008},
  volume={26 7},
  pages={1112-8}
}
PURPOSE To estimate the cumulative incidence of specific hormone deficiencies and the influence of hypothalamic-pituitary (HP) axis radiation dose in a cohort of children with embryonal brain tumors treated with risk-adapted craniospinal irradiation (CSI), conformal primary site irradiation, and high-dose chemotherapy. PATIENTS AND METHODS Clinical data and HP axis radiation dosimetry data were obtained from 88 eligible children. All patients received regular endocrine follow-up that included… CONTINUE READING

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