Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.

Abstract

We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)-FGF15/19 and FGF21-that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has… (More)
DOI: 10.1101/gad.184788.111

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