Endocrine disruptors in the etiology of type 2 diabetes mellitus

@article{AlonsoMagdalena2011EndocrineDI,
  title={Endocrine disruptors in the etiology of type 2 diabetes mellitus},
  author={Paloma Alonso-Magdalena and Iv{\'a}n Quesada and Angel Nadal},
  journal={Nature Reviews Endocrinology},
  year={2011},
  volume={7},
  pages={346-353}
}
The etiology of type 2 diabetes mellitus involves the induction of insulin resistance along with the disruption of pancreatic β-cell function and the loss of β-cell mass. In addition to a genetic predisposition, lifestyle factors seem to have an important role. Epidemiological studies indicate that the increased presence of endocrine disrupting chemicals (EDCs) in the environment may also play an important part in the incidence of metabolic diseases. Widespread EDCs, such as dioxins, pesticides… 
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Highly Influential Citations
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Background Citations
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Bisphenol A and Type 2 Diabetes Mellitus: A Review of Epidemiologic, Functional, and Early Life Factors
TLDR
Type 2 diabetes mellitus (T2DM) is characterised by insulin resistance and eventual pancreatic β-cell dysfunction, resulting in persistent high blood glucose levels, and BPA is a pervasive EDC, being the main constituent of polycarbonate plastics.
Endocrine disruptors: new players in the pathophysiology of type 2 diabetes?
Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes.
TLDR
It is concluded that MDC-induced mitochondrial dysfunction, which is mainly characterized by perturbations in mitochondrial bioenergetics, biogenesis and dynamics, excessive reactive oxygen species production and activation of the mitochondrial pathway of apoptosis, seems to be a relevant mechanism linking MDCs to type 2 diabetes development.
Exposure to bisphenol a and risk of developing type 2 diabetes: A mini review
Endocrine Disruption and Disorders of Energy Metabolism
Bisphenol A: Targeting metabolic tissues
TLDR
Both epidemiological evidence and in vivo experimental data point to an association between BPA exposure and the induction of insulin resistance and/ or disruption of pancreatic beta cell function and/or obesity.
Endocrine-disrupting chemicals and fatty liver disease
TLDR
This work focuses on one class of endocrine-disrupting chemicals (EDCs) and their potential to influence the initiation and progression of a cascade of pathological conditions associated with hepatic steatosis (fatty liver), and several potential mechanisms by which EDC exposure might contribute to disease pathogenesis.
MECHANISMS IN ENDOCRINOLOGY: Metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes.
TLDR
The main mechanisms involved in the activation of obesity-associated metabolic inflammation are presented and potential therapeutic opportunities that can be developed to treat obesity- associated metabolic diseases are discussed.
Bisphenol-A treatment during pregnancy in mice: a new window of susceptibility for the development of diabetes in mothers later in life.
TLDR
It is shown that several months after delivery, mothers treated with the widespread EDC bisphenol-A (BPA) during gestation, at environmentally relevant doses, exhibit profound glucose intolerance and altered insulin sensitivity as well as increased body weight.
Adverse Effects of Bisphenol A Exposure on Glucose Metabolism Regulation
TLDR
Exposure to BPA seems to be an important risk factor in the onset of obesity and metabolic syndrome, however, its mechanisms of action need to be further investigated to provide a major evaluation of risk assessment.
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