Endocrine disruptors affect developmental programming of HOX gene expression.


HOX gene expression determines the differential developmental identity of the Müllerian duct. Diethylstilbestrol and several environmental xenoestrogens disrupt the development of the female reproductive tract by altering HOX gene expression, leading to structural and functional defects. 
DOI: 10.1016/j.fertnstert.2007.12.030


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