Endocrine disruptors: update on xenoestrogens

  title={Endocrine disruptors: update on xenoestrogens},
  author={Gisela H Degen and Hermann M. Bolt},
  journal={International Archives of Occupational and Environmental Health},
  • G. Degen, H. Bolt
  • Published 1 September 2000
  • Medicine
  • International Archives of Occupational and Environmental Health
Abstract Endocrine disruptors and their possible impact on human and animal health have become a topic of discussion and an area of active research in toxicology. A focus has been on xenoestrogens, i.e., environmental chemicals with estrogenic activity. In principle, there is agreement that such compounds, in high doses, may cause developmental, reproductive and tumorigenic effects (“hazard”). A matter of controversy is the question of risks associated with xenoestrogens under realistic (low… 
Xenoestrogen exposure and mechanisms of endocrine disruption.
Environmental xenoestrogens can be divided into natural compounds (e.g. from plants or fungi), and synthetically derived agents including certain drugs, pesticides and industrial by-products, which are thought to have a number of beneficial actions.
Comparative assessment of endocrine modulators with oestrogenic activity. II. Persistent organochlorine pollutants
An HBMOS of 137 is derived for o,p'-DDT indicative of a sufficient margin of safety to ensure the absence of risk to human health due to its hormonal action, under exposure conditions now prevailing in Western countries.
The endocrine and reproductive system: adverse effects of hormonally active substances?
Although there are still open questions regarding in utero or early postnatal exposure, the low potencies and concentrations of manmade chemicals as compared with the endogenous hormones in humans make it unlikely that adverse effects occur at common exposure.
Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor Pathways
Different molecular actions of some of the major xenoestrogens found in food or the environment are discussed, and the current models used to evaluate environmental estrogens are summarized.
[Occupational exposure to endocrine disruptors: state of the art].
Considering the broad range of equilibria and systems on which endocrine destructive compounds can act, the international scientific community needs to persist in its efforts to develop methods for checking the effects on other endocrine organs--particularly the thyroid gland--and on the immune and neurological systems.
Estimation of the Mean AUC of the Xenoestrogens Daidzein, Bisphenol A, and p-tert-Octylphenol
The toxicokinetics and the bioavailability of these three substances in female DA/Han rats after oral and single intravenous application were investigated by the use of population models accounting for the differences in the individual metabolism.
Comparison of the toxicokinetics of daidzein and bisphenol A in pregnant and non-pregnant DA/Han rats
The toxicokinetics of these compounds in female pregnant and non-pregnant DA/Han rats after single intravenous application were compared by the use of the Mann-Whitney- U-statistic.
Endocrine disrupting compounds exposure and testis development in mammals
Previous studies are reviewed to highlight the extent to which testis development can be disrupted during fetal life, and the level of fetal exposure to endocrine disrupting compounds can only be roughly estimated.