Endocrine disruptors, gene deregulation and male germ cell tumors.

@article{DelMazo2013EndocrineDG,
  title={Endocrine disruptors, gene deregulation and male germ cell tumors.},
  author={Jes{\'u}s Del-Mazo and Miguel A Brie{\~n}o-Enr{\'i}quez and Jes{\'u}s Garc{\'i}a-L{\'o}pez and Luis Andr{\'e}s L{\'o}pez-Fern{\'a}ndez and Massimo De-Felici},
  journal={The International journal of developmental biology},
  year={2013},
  volume={57 2-4},
  pages={225-39}
}
Endocrine disruptors (EDs) belong to a large group of compounds, usually present as environmental pollutants, which can alter the homeostasis of living organisms by modifying hormonal balance and changing the normal patterns of gene regulation during development and cell differentiation. Hence, the development of male gonads and their functionality may be affected by exposure to specific EDs or their mixtures. The molecular mechanisms of action of these reprotoxicants leading to pathologies of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Gonadal development and germ cell tumors in mouse and humans.

Seminars in cell & developmental biology • 2015
View 16 Excerpts
Highly Influenced

Male Reproductive Cancers and Infertility: A Mutual Relationship

International journal of molecular sciences • 2015
View 9 Excerpts
Highly Influenced

Male infertility as a proxy of the overall male health status.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology • 2018

References

Publications referenced by this paper.
Showing 1-10 of 186 references

A role for Lin 28 in primordial germcell development and germcell malignancy

J. A. WEST, S. R. VISWANATHAN, +7 authors A. L. FRAZIER
Nature • 2009
View 9 Excerpts
Highly Influenced

Specification of germ cell fate in mice.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2003
View 3 Excerpts
Highly Influenced

Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction

R. M. SHARPE, N. E. SKAKKEBAEK
1993
View 5 Excerpts
Highly Influenced

The biology of primordial germ cells.

European urology • 1993
View 1 Excerpt
Highly Influenced

Similar Papers

Loading similar papers…