Endocrine disruptor effect of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on porcine ovarian cell steroidogenesis.

@article{ChaparroOrtega2018EndocrineDE,
  title={Endocrine disruptor effect of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on porcine ovarian cell steroidogenesis.},
  author={Andrea Chaparro-Ortega and Miguel Angel Betancourt and Patricia Rosas and F G V{\'a}zquez-Cuevas and Roberto Chavira and Edmundo Bonilla and Eduardo Casas and Yvonne Ducolomb},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2018},
  volume={46},
  pages={
          86-93
        }
}
Previous studies with perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) indicate that they act as endocrine disruptors, in addition to inducing alterations and damaging reproductive health; however, the biological mechanisms by which these disorders are produced are not yet understood. The aim of this study was to analyze the effect of PFOS and PFOA on in vitro steroidogenic secretion in porcine theca and granulosa cells, with or without gonadotropic stimulation. Granulosa… CONTINUE READING