Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa.

@article{Han2010EndocrineDA,
  title={Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa.},
  author={Sunyoung Han and Kyungho Choi and Jungkon Kim and Kyunghee Ji and Sunmi Kim and Byeongwoo Ahn and Junheon Yun and Kyunghee Choi and Jong Seong Khim and Xiaowei Zhang and John Paul Giesy},
  journal={Aquatic toxicology},
  year={2010},
  volume={98 3},
  pages={256-64}
}
Despite frequent detection of ibuprofen in aquatic environments, the hazards associated with long-term exposure to ibuprofen have seldom been investigated. Ibuprofen is suspected of influencing sex steroid hormones through steroidogenic pathways in both vertebrates and invertebrates. In this study, the effect of ibuprofen on sex hormone balance and the associated mechanisms was investigated in vitro by use of H295R cells. We also conducted chronic toxicity tests using freshwater fish, Oryzias… CONTINUE READING

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