Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis.

@article{Frizzell2011EndocrineDE,
  title={Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis.},
  author={Caroline Frizzell and Doreen Ndossi and Steven Verhaegen and Ellen Dahl and Gunnar Sundst\ol Eriksen and Morten S\orlie and Erik Ropstad and Marc Muller and Christopher Trevor Elliott and Lisa M Connolly},
  journal={Toxicology letters},
  year={2011},
  volume={206 2},
  pages={210-7}
}
The mycotoxin zearalenone (ZEN) is a secondary metabolite of fungi which is produced by certain species of the genus Fusarium and can occur in cereals and other plant products. Reporter gene assays incorporating natural steroid receptors and the H295R steroidogenesis assay have been implemented to assess the endocrine disrupting activity of ZEN and its metabolites α-zearalenol (α-ZOL) and β-zearalenol (β-ZOL). α-ZOL exhibited the strongest estrogenic potency (EC(50) 0.022±0.001 nM), slightly… CONTINUE READING
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