Endocrine disorders and hormonal therapy for adolescent acne

  title={Endocrine disorders and hormonal therapy for adolescent acne},
  author={Henry L. Nguyen and Megha M. Tollefson},
  journal={Current Opinion in Pediatrics},
Purpose of review Acne vulgaris is a global disease with increasing prevalence in adolescents. It has a profound impact on their quality of life, especially when endocrine disorders are also involved. Recent concerns regarding antibiotic stewardship, failures with antibiotic usage, and the development of antibiotic-resistant Propionibacterium acnes have led clinicians to consider other therapeutic options for acne treatment. The present review explores hormonal therapies for the treatment of… 

Update in the management of acne in adolescence

An effective acne management strategy targets multiple pathogenic factors in acne, using a retinoid as the foundation, and should be used for acute management, then discontinued at 3–4 months, while maintaining on topical treatments.

Complex correction of psychoemotional and immunological changes in patients with acne

Effectiveness therapy with phabomotizol was shown and presence of immunotropic properties of IL was established, and possibility of achieving long-term remission without the use of antibiotic therapy was demonstrated.

Formulation and evaluation of polyherbal anti-acne combination by using in-vitro model

This study has estimated the chemical constituents and phytochemicals present in these plants and their activity against Propionibacterium acne, and prepared a formulation using all the three plants and tested them for their activity and drug release with the time.

Truncal Acne: An Overview

The epidemiology, etiology, severity assessment tool, assessments of the quality of life, and new treatments targeting truncal acne are currently being studied.

Prevalence, Awareness and Psychological Impact of Acne Vulgaris among University Students

Very poor level of awareness and knowledge about etiology and associated aggravating factors of acne is found among Majmaah university students, affecting both sexes, and strong association of acne with severe psychological impact is evident.


High levels of anxiety and depression in patients with facial acne are not related to oxidative stress, according to a study published online in the Journal of Cosmetic Dermatology.

Acne Protection: Measures & Miseries

Age, in particular, has a significant and well-known impact, as sebum levels are usually low in childhood, rise in the middle-to-late teen years, and remain stable into the seventh and eighth decades until endogenous androgen synthesis dwindles.

International Journal of Clinical & Experimental Dermatology Acne Vulgaris: Pimples No Not Have Simple Solution

Age, in particular, has a significant and well-known impact, as sebum levels are usually low in childhood, rise in the middle-to-late teen years, and remain stable into the seventh and eighth decades until endogenous androgen synthesis dwindles.

What does acne genetics teach us about disease pathogenesis?

Familial preponderance clearly indicates a genetic basis for acne vulgaris, but until recently solid genetic associations were lacking.

Androgen-related disorders and hormone therapy for patients with keloids



Evidence-based approach to cutaneous hyperandrogenism in women.

Hormonal Contraceptives and Acne: A Retrospective Analysis of 2147 Patients.

INTRODUCTION Although hormonal contraceptives may help acne or worsen it, there is limited evidence on the effects of many commonly prescribed agents. The present study evaluates patient-reported

Combined oral contraceptive pills for treatment of acne.

A large number of placebo-controlled trials showed COCs reduced acne lesion counts, severity grades and self-assessed acne compared to placebo, and were more likely to have a clinician assessment of clear or almost clear lesions and participantself-assessment of improved acne lesions.

Update and Future of Hormonal Therapy in Acne

Recent research over the past several years has unraveled some of the details regarding the way that the skin and sebaceous glands synthesize and metabolize hormones, providing an impetus for future drug discovery in the hormonal treatment of acne.

Clinical Profiles, Occurrence, and Management of Adolescent Patients with HAIR-AN Syndrome

It is concluded that HAIR-AN syndrome is a common disease in young women and multifaceted, aggressive treatment appears to be effective in reducing the severity of symptoms and preventing further consequences.

Treatment with a gonadotropin-releasing hormone agonist in acne or idiopathic hirsutism

Six women with acne and six women with hirsutism were treated with the GnRH analog [D-Ser(But)6] LHRH-(1–9)ethylamide (Buserelin®) for 6 months (nasal spray, 1,200 μg/day) to suppress ovarian

Polycystic ovary syndrome in adolescents: a review of past year evidence

A critical assessment of recent literature on PCOS in adolescents is put forth, with particular focus on new information regarding the pathogenesis, diagnosis, associated morbidities, and management.

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

Recommendations are put forth regarding the classification, diagnosis, evaluation, and management of pediatric acne, based on age and pubertal status including issues of special concern when treating pediatric patients.

Low-dose adjunctive spironolactone in the treatment of acne in women: a retrospective analysis of 85 consecutively treated patients.

  • J. C. Shaw
  • Medicine
    Journal of the American Academy of Dermatology
  • 2000
Spironolactone can be used in low doses as a single drug or as an adjunct to standard acne therapies in women with adult acne, and when used in this fashion, treatment outcomes are favorable, and the drug is well tolerated.