Endocrine composition of follicular fluid comparing human chorionic gonadotrophin to a gonadotrophin-releasing hormone agonist for ovulation induction.

@article{YdingAndersen1993EndocrineCO,
  title={Endocrine composition of follicular fluid comparing human chorionic gonadotrophin to a gonadotrophin-releasing hormone agonist for ovulation induction.},
  author={Claus Yding Andersen and Lars Grabow Westergaard and Yngve Figenschau and Kjell Bertheussen and Finn Forsdahl},
  journal={Human reproduction},
  year={1993},
  volume={8 6},
  pages={
          840-3
        }
}
Concentrations of inhibin, oestradiol and progesterone were determined in pre-ovulatory follicular fluid from 16 women undergoing in-vitro fertilization and embryo transfer treatment. A prospective randomized design was used such that ovulation was induced in eight women with human chorionic gonadotrophin (HCG) (9000 IU), and in eight women with an endogenous surge of luteinizing hormone (LH) and follicle stimulating hormone (FSH) caused by a single injection of gonadotrophin-releasing hormone… 
Hormonal characteristics of follicular fluid from women receiving either GnRH agonist or hCG for ovulation induction.
TLDR
It is suggested that GnRH agonist results in proper pre-ovulatory follicular maturation, but the ovulatory signal--probably in synergy with the resulting pituitary down-regulation--is too low to support appropriate corpus luteum (CL) function.
Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization.
TLDR
After treatment with the GnRH antagonist ganirelix for the prevention of premature LH surges, triggering of final stages of oocyte maturation can be induced effectively by a single bolus injection of GnRH agonist, as demonstrated by the induced endogenous LH and FSH surge and the quality and fertilization rate of recovered oocytes.
Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology.
TLDR
To evaluate the effectiveness and safety of GnRH agonists in comparison with HCG for triggering final oocyte maturation in IVF and ICSI for women undergoing COH in a GnRH antagonist protocol, databases were searched and primary outcomes were live birth and rate of ovarian hyperstimulation syndrome (OHSS) per women randomised.
Effect of GnRHa ovulation trigger dose on follicular fluid characteristics and granulosa cell gene expression profiles
TLDR
In women co-treated with a GnRH antagonist, no significant differences in FF steroid levels and granulosa cell gene expression were seen when different triptorelin doses were used to trigger final oocyte maturation.
Individual luteolysis pattern after GnRH-agonist trigger for final oocyte maturation
TLDR
It was concluded, that luteolysis after GnRH-agonist trigger is patient-specific and also luteal phase support requires individualization, and longer stimulation duration as well as a higher level of progesterone on the day of final oocyte maturation and more retrieved oocytes will result in higher levels of progestersone 48 hours after oocyte retrieval.
Individual luteolysis post GnRH-agonist-trigger in GnRH-antagonist protocols
TLDR
Assessment of estradiol (E2)- and P4-levels 48 h after oocyte-pick-up (OPU) procedure demonstrate clearly, that luteolysis after GnRH-agonist trigger is individual-specific, even in high-responder patients with the same number of oocytes, indicating individualization of luteal phase support with the focus on avoiding unnecessary administration of hCG.
GnRH agonist triggering affects the kinetics of embryo development: a comparative study
TLDR
Time-lapse analysis revealed that embryos from cycles triggered by a GnRHa cleaved faster than embryos derived from hCG-triggered cycles, suggesting thatTriggering with a Gn RHa in in vitro fertilization cycles affects embryo kinetics.
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