Endocrine care of transpeople part I. A review of cross‐sex hormonal treatments, outcomes and adverse effects in transmen

@article{Meriggiola2015EndocrineCO,
  title={Endocrine care of transpeople part I. A review of cross‐sex hormonal treatments, outcomes and adverse effects in transmen},
  author={Maria Cristina Meriggiola and Giulia Gava},
  journal={Clinical Endocrinology},
  year={2015},
  volume={83}
}
Gender dysphoria (GD) is characterized by discomfort with the assigned or birth gender and the urge to live as a member of the desired sex. The goal of medical and surgical treatment is to improve the well‐being and quality of life of transpeople. The acquisition of phenotypic features of the desired gender requires the use of cross‐sex hormonal therapy (CHT). Adult transmen are treated with testosterone to induce virilization. In adolescents with severe and persistent GD, consideration can be… Expand
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References

SHOWING 1-10 OF 152 REFERENCES
Cross-sex hormone therapy in trans persons is safe and effective at short-time follow-up: results from the European network for the investigation of gender incongruence.
TLDR
Current treatment modalities were effective and carried a low risk for side effects and adverse events at short-time follow-up, and side effects, adverse events, and desired clinical changes were examined. Expand
Clinical management of gender identity disorder in adolescents: a protocol on psychological and paediatric endocrinology aspects
TLDR
Preliminary findings suggest that a decrease in height velocity and bone maturation occurs, and GnRHa treatment appears to be an important contribution to the clinical management of gender identity disorder in transsexual adolescents. Expand
Is hormonal therapy associated with better quality of life in transsexuals? A cross-sectional study.
TLDR
A positive effect of hormone therapy on transsexuals' QoL is suggested after accounting for confounding factors, which will be useful for healthcare providers of transgender persons but should be confirmed with larger samples using a prospective study design. Expand
Effects of three different testosterone formulations in female-to-male transsexual persons.
TLDR
One-year testosterone administration in FtM transsexuals appears to be very safe with no differences among the testosterone formulations used and the detection of subtle or long-term differences in the effects of the three formulations may require further larger and longer term studies in this and other populations. Expand
Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience.
TLDR
Cross-sex hormone treatment of transsexuals seems acceptably safe over the short and medium term, but solid clinical data are lacking. Expand
Endocrine treatment of transsexual people: a review of treatment regimens, outcomes, and adverse effects.
TLDR
The range of treatment used by transsexual people, the rationale behind these, and the expectation from such treatment are discussed, as well as the potential adverse effects of cross-sex hormone treatment of transsexual people. Expand
Effect of long-term testosterone administration on the endometrium of female-to-male (FtM) transsexuals.
TLDR
The data suggest that exogenous T administration does not stimulate endometrial proliferation in FtM transsexuals and indeed may have atrophic effects. Expand
Long-term cross-sex hormone treatment is safe in transsexual subjects.
TLDR
It is suggested that mortality is increased among transsexuals although due to causes unrelated to cross sex replacement therapy, which will benefit the care and treatment of these subjects. Expand
Management of transgenderism.
TLDR
Hormone treatment for both FTM and MTF can be started in early puberty, although long-term effects are not known, and all patients considering treatment need counseling and medical monitoring. Expand
Endocrine treatment of transsexual persons: an Endocrine Society Clinical Practice Guideline: commentary from a European perspective.
TLDR
These guidelines are structured to provide evidence-based suggestions or, where evidence is lacking, expert recommendations on diagnostic procedures and hormonal treatment in adolescent and adult transsexuals, including long-term care and eligibility for surgery. Expand
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