Endocrine and immunohistochemical studies on thyrotropin (TSH)-secreting pituitary adenomas: responses of TSH, alpha-subunit, and growth hormone to hypothalamic releasing hormones and their distribution in adenoma cells.

@article{Kuzuya1990EndocrineAI,
  title={Endocrine and immunohistochemical studies on thyrotropin (TSH)-secreting pituitary adenomas: responses of TSH, alpha-subunit, and growth hormone to hypothalamic releasing hormones and their distribution in adenoma cells.},
  author={Nobuaki Kuzuya and Kinji Inoue and M. Ishibashi and Yoichi Murayama and Yuji Koide and Koichi Ito and Tohru Yamaji and Kamejiro Yamashita},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1990},
  volume={71 5},
  pages={1103-11}
}
Endocrine and immunohistochemical studies were performed in two cases of TSH-secreting pituitary adenomas. The patients had elevated serum TSH and alpha-subunit concentrations despite high serum thyroid hormone levels. In addition, one patient (no. 1) had elevated serum GH levels with clinical evidence of acromegaly. GH-releasing hormone infusion increased serum levels of TSH, alpha-subunit and GH in the two patients. TRH injection increased serum TSH levels in both patients and, concomitantly… CONTINUE READING