Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population.

@article{Barker2005EndocrineAI,
  title={Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population.},
  author={Jennifer M. Barker and Akane Ide and Corey Hostetler and Liping Yu and Dongmei Miao and Pamela R. Fain and George S. Eisenbarth and Peter A. Gottlieb},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 1},
  pages={
          128-34
        }
}
Individuals with type 1 diabetes mellitus (T1D) at risk for Addison's disease (AD) can be identified with RIAs for autoantibodies to the adrenal antigen 21-hydroxylase (21-OHAA). Screening individuals with T1D for 21OH-AA shows a relatively high prevalence of positive autoantibodies (1.4%, 38 of 2696 subjects). After detection of 21-OHAA, individuals were evaluated with endocrine testing, including baseline cortisol, ACTH, and plasma renin activity and low (1 mug) and high (250 mug) dose… CONTINUE READING
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