Endocrine and gene expression changes following forced swim stress exposure during cocaine abstinence in mice

@article{Cleck2008EndocrineAG,
  title={Endocrine and gene expression changes following forced swim stress exposure during cocaine abstinence in mice},
  author={Jessica N. Cleck and Laurel E. Ecke and Julie A. Blendy},
  journal={Psychopharmacology},
  year={2008},
  volume={201},
  pages={15-28}
}
RationaleStress can reinstate previous cocaine-seeking long after drug is no longer present. However, little is known regarding the effect of chronic drug exposure and subsequent drug abstinence on responsivity to stress.ObjectiveTo determine the effect of acute (24-h) and prolonged (14-day) drug-free periods in cocaine-experienced mice on behavioral, endocrine, and molecular outputs following stress exposure.Materials and methodsMice were administered a cocaine binge (15mg/kg, every hour for… CONTINUE READING

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