Endocrine abnormalities of obesity.

  title={Endocrine abnormalities of obesity.},
  author={Per Bj{\"o}rntorp},
  journal={Metabolism: clinical and experimental},
  volume={44 9 Suppl 3},
Studies have shown that patients with central obesity have increased cortisol secretion, probably because they have increased activity of the hypothalamic-pituitary-adrenal (HPA) axis. A high waist-to-hip ratio (WHR) is associated with low production of sex steroids, such as testosterone in men, and a low rate of secretion of growth hormone. High levels of cortisol and insulin combined with low levels of growth hormone and sex steroid can cause lipid accumulation. These hormonal changes… CONTINUE READING
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