Endocrine Treatment of Gender‐Dysphoric/Gender‐Incongruent Persons: An Endocrine Society* Clinical Practice Guideline

@article{Hembree2017EndocrineTO,
  title={Endocrine Treatment of Gender‐Dysphoric/Gender‐Incongruent Persons: An Endocrine Society* Clinical Practice Guideline},
  author={Wylie C. Hembree and Peggy T Cohen-Kettenis and Louis J Gooren and Sabine Elisabeth Hannema and Walter J. Meyer and Hassan Murad and Stephen M. Rosenthal and Joshua D Safer and Vin Tangpricha and Guy T’Sjoen},
  journal={The Journal of Clinical Endocrinology \& Metabolism},
  year={2017},
  volume={102},
  pages={3869–3903}
}
Objective: To update the “Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline,” published by the Endocrine Society in 2009. Participants: The participants include an Endocrine Society‐appointed task force of nine experts, a methodologist, and a medical writer. Evidence: This evidence‐based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the… 

Tables from this paper

Emerging topics in transgender medicine

  • V. Tangpricha
  • Medicine
    Reviews in Endocrine and Metabolic Disorders
  • 2018
It is found that there still remains a large majority of physicians who lack the expertise in transgender medicine and several interventions that have been effective in reducing this gap are reviewed.

Endocrine treatment of transgender individuals: current guidelines and strategies

This review summarizes gender affirming medical and surgical care available to transgender individuals, along with proposals to improve medically and culturally appropriate care.

Gender-affirming hormones and surgery in transgender children and adolescents.

Endocrinology of Transgender Medicine.

Recent data on hormonal treatment of transgender people and its effect on physical, psychological, and mental health is reviewed to provide evidence as to the effect of gender-affirming treatment in the nonbinary population.

Transgender adults, gender-affirming hormone therapy and blood pressure: a systematic review

There is currently insufficient data to advise the impact of GHT on BP in transgender individuals and better quality research is essential to elucidate whether exogenous sex hormones modulateBP in transgender people and whether this putative alteration infers poorer cardiovascular outcomes.

SIGIS–SIAMS–SIE position statement of gender affirming hormonal treatment in transgender and non-binary people

This Position statement proposes experts opinions concerning the psychological functioning of transgender people, the gender-affirming hormonal treatment, the emerging issues in transgender health care aimed to improve patient care, and an overview of Italian law about gender affirming surgery and registry rectification.

Gender Incongruence

  • G. Butler
  • Medicine, Psychology
    Encyclopedia of Evolutionary Psychological Science
  • 2020
Gender dysphoria is a disassociation with birth gender and identification with the opposite gender, and it is not considered similar to a disorder of sex development.

Routine Screening for Transgender and Gender Diverse Adults Taking Gender-Affirming Hormone Therapy: a Narrative Review

A narrative review of TGD-specific screening recommendations from several major medical organizations and programs found them to be largely based upon expert opinion due to a lack of evidence.

Progesterone Is Important for Transgender Women’s Therapy—Applying Evidence for the Benefits of Progesterone in Ciswomen

  • J. Prior
  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 2019
Accumulated evidence indicates that normally ovulatory menstrual cycles are necessary for ciswomen's current fertility, as well as for later-life bone and cardiovascular health and the prevention of breast and endometrial cancers, and transgender women deserve progesterone therapy and similar potential physiological benefits.

Fertility preservation for transgender adolescents and young adults: a systematic review.

From a synthesis of the literature, it is concluded that there are many barriers preventing TAYAs from pursuing FP, including a lack of awareness of FP options, high costs, invasiveness of the available procedures and the potential psychological impact of the FP process.
...

References

SHOWING 1-10 OF 296 REFERENCES

Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline.

This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe the strength of recommendations and the quality of evidence, which was low or very low.

Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline.

The Task Force recommends testosterone therapy for symptomatic men with androgen deficiency, who have low testosterone levels, to induce and maintain secondary sex characteristics and to improve their sexual function, sense of well-being, muscle mass and strength, and bone mineral density.

A European Network for the Investigation of Gender Incongruence: Endocrine Part.

Endocrine treatment of transsexual people: a review of treatment regimens, outcomes, and adverse effects.

The range of treatment used by transsexual people, the rationale behind these, and the expectation from such treatment are discussed, as well as the potential adverse effects of cross-sex hormone treatment of transsexual people.

Endocrinologic treatment of gender identity disorders.

Physicians caring for patients with transsexualism should have a general knowledge about the diagnosis, available treatment, and monitoring for complications of hormonal therapy.

The effect of cross-sex hormonal treatment on gender dysphoria individuals’ mental health: a systematic review

It is indicated that gender dysphoria-related mental distress may benefit from hormonal treatment intervention, suggesting a transient reaction to the nonsatisfaction connected to the incongruent body image rather than a stable psychiatric comorbidity.

Endocrine care of transpeople part I. A review of cross‐sex hormonal treatments, outcomes and adverse effects in transmen

Monitoring of transmen should be more frequent during the first year of cross‐sex hormone administration reducing to once or twice per year thereafter, and long‐term monitoring after sex reassignment surgery (SRS) includes annual check‐ups as are carried out for natal hypogonadal men.

Consensus Statement on the Use of Gonadotropin-Releasing Hormone Analogs in Children

The conference did not endorse commonly voiced concerns regarding the use of gonadotropin-releasing hormone analogs, such as promotion of weight gain or long-term diminution of bone mineral density.

Gender Identity Disorder: General Overview and Surgical Treatment for Vaginoplasty in Male-to-Female Transsexuals

The penile-scrotal skin flap technique is considered the state of the art for vaginoplasty in male-to-female transsexuals, whereas other techniques (rectosigmoid flap, local flaps, and isolated skin grafts) should be considered only in secondary cases.

The treatment of adolescent transsexuals: changing insights.

The pros and cons of the various approaches to youngsters with GID are presented, hopefully inciting a sound scientific discussion of the issue.
...