Endocrine Treatment of Gender‐Dysphoric/Gender‐Incongruent Persons: An Endocrine Society* Clinical Practice Guideline

@article{Hembree2017EndocrineTO,
  title={Endocrine Treatment of Gender‐Dysphoric/Gender‐Incongruent Persons: An Endocrine Society* Clinical Practice Guideline},
  author={Wylie C. Hembree and Peggy T Cohen-Kettenis and Louis J Gooren and Sabine E Hannema and Walter J. Meyer and Hassan Murad and Stephen M. Rosenthal and Joshua D Safer and Vin Tangpricha and Guy T’Sjoen},
  journal={The Journal of Clinical Endocrinology \& Metabolism},
  year={2017},
  volume={102},
  pages={3869–3903}
}
Objective: To update the “Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline,” published by the Endocrine Society in 2009. Participants: The participants include an Endocrine Society‐appointed task force of nine experts, a methodologist, and a medical writer. Evidence: This evidence‐based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the… Expand
2017 AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/ENDOCRINE SOCIETY UPDATE ON TRANSGENDER MEDICINE: CASE DISCUSSIONS.
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Endocrinologists should be familiar with the revised guidelines for gender-dysphoric and gender-nonconforming persons, as important aspects of care are the diagnosis of gender dysphoria, the timing of treatment with gender-affirming hormones, and the long-term monitoring for potential adverse outcomes. Expand
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References

SHOWING 1-10 OF 297 REFERENCES
Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline.
TLDR
This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe the strength of recommendations and the quality of evidence, which was low or very low. Expand
A European Network for the Investigation of Gender Incongruence: Endocrine Part.
TLDR
A detailed description of the study protocol, objectives, and design of the ENIGI Endocrine protocol is given, which aims to evaluate clinical and side-effects of cross-sex hormonal treatment in trans persons. Expand
Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline.
TLDR
The Task Force recommends testosterone therapy for symptomatic men with androgen deficiency, who have low testosterone levels, to induce and maintain secondary sex characteristics and to improve their sexual function, sense of well-being, muscle mass and strength, and bone mineral density. Expand
Endocrine treatment of transsexual people: a review of treatment regimens, outcomes, and adverse effects.
TLDR
The range of treatment used by transsexual people, the rationale behind these, and the expectation from such treatment are discussed, as well as the potential adverse effects of cross-sex hormone treatment of transsexual people. Expand
Endocrinologic treatment of gender identity disorders.
TLDR
Physicians caring for patients with transsexualism should have a general knowledge about the diagnosis, available treatment, and monitoring for complications of hormonal therapy. Expand
The effect of cross-sex hormonal treatment on gender dysphoria individuals’ mental health: a systematic review
TLDR
It is indicated that gender dysphoria-related mental distress may benefit from hormonal treatment intervention, suggesting a transient reaction to the nonsatisfaction connected to the incongruent body image rather than a stable psychiatric comorbidity. Expand
Endocrine care of transpeople part I. A review of cross‐sex hormonal treatments, outcomes and adverse effects in transmen
TLDR
Monitoring of transmen should be more frequent during the first year of cross‐sex hormone administration reducing to once or twice per year thereafter, and long‐term monitoring after sex reassignment surgery (SRS) includes annual check‐ups as are carried out for natal hypogonadal men. Expand
Consensus Statement on the Use of Gonadotropin-Releasing Hormone Analogs in Children
TLDR
The conference did not endorse commonly voiced concerns regarding the use of gonadotropin-releasing hormone analogs, such as promotion of weight gain or long-term diminution of bone mineral density. Expand
Gender Identity Disorder: General Overview and Surgical Treatment for Vaginoplasty in Male-to-Female Transsexuals
TLDR
The penile-scrotal skin flap technique is considered the state of the art for vaginoplasty in male-to-female transsexuals, whereas other techniques (rectosigmoid flap, local flaps, and isolated skin grafts) should be considered only in secondary cases. Expand
The treatment of adolescent transsexuals: changing insights.
TLDR
The pros and cons of the various approaches to youngsters with GID are presented, hopefully inciting a sound scientific discussion of the issue. Expand
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