Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue

  title={Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue},
  author={Shu Q. Liu and Derek T Roberts and Alexei Kharitonenkov and Brian Zhang and Samuel M. Hanson and Yan Li and Li-Qun Zhang and Yu Hou Wu},
  booktitle={Scientific reports},
Myocardial ischemia, while causing cardiomyocyte injury, can activate innate protective processes, enhancing myocardial tolerance to ischemia. Such processes are present in not only the heart, but also remote organs. In this investigation, we demonstrated a cardioprotective process involving FGF21 from the liver and adipose tissue. In response to myocardial ischemia/reperfusion injury in the mouse, FGF21 was upregulated and released from the hepatic cells and adipocytes into the circulation and… CONTINUE READING
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