Endocrine Function in the Prader-Willi Syndrome

  title={Endocrine Function in the Prader-Willi Syndrome},
  author={William J Jeffcoate and Bernard M Laurance and G. Michael Besser and Christopher R. W. Edwards},
  journal={Pediatric Research},
Five males and 2 females with the Prader-Willi Syndrome, aged 10-26 years, had low levels of circulating LH with a subnormal response to 100 and 500 mcg of gonadotrophin releasing hormone (Gn-RH) IV. Serum FSH response to Gn-RH was absent in 3, but normal in only one. Gonadotrophin response to Gn-RH increased in 4 patients during oral clomiphene (200 mg daily) given one to 6 weeks. This suggests that the pituitary gonadotrophes can function normally and that the deficiency is hypothalamic. Five… CONTINUE READING


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