Endocrine Factors Determining Immune Polarization during Perinatal Transition.

@article{Vsrhelyi2017EndocrineFD,
  title={Endocrine Factors Determining Immune Polarization during Perinatal Transition.},
  author={Barna V{\'a}s{\'a}rhelyi and Tivadar Tulassay},
  journal={Klinische Padiatrie},
  year={2017},
  volume={229 5},
  pages={261-266}
}
In utero the skewness of the adaptive immune system towards Th2 ('antiinflammatory') direction and low of Th1/Th2 cell ratio defend the fetus against rejection by the maternal immune system. Th2 dominance at birth is also of importance as it prevents uncontrolled inflammatory processes during parturition. This condition should change rapidly after birth. In an extrauterine milieu that is inherent with exposure to microorganisms, Th1 ('proinflammatory') polarization (i. e. increased Th1 cytokine… CONTINUE READING