Corpus ID: 33003240

Endocervical columnar cell atypia coincident with cervical neoplasia characterized by digital image analysis.

@article{Rosenthal1982EndocervicalCC,
  title={Endocervical columnar cell atypia coincident with cervical neoplasia characterized by digital image analysis.},
  author={Dorothy L. Rosenthal and C McLatchie and E Stern and Benjamin S. White and Kenneth R. Castleman},
  journal={Acta cytologica},
  year={1982},
  volume={26 2},
  pages={
          115-20
        }
}
In the course of classifying uterine cervical epithelial cells for digital image analysis, certain changes in endocervical cells were observed. These changes coincided with the process ongoing in the squamous or metaplasia epithelium. Specifically, in severe dysplasias or carcinomas in situ (CIS), the endocervical nuclei reflected some of the same cytologic changes observed in the dysplastic or CIS squamous cells and yet definitely retained their columnar shape and cytoplasmic quality. This… Expand
Cervical glandular atypia associated with squamous intraepithelial neoplasia: a premalignant lesion?
TLDR
The endocervical mucosa in 105 cases of CIN grade III was evaluated and compared with that of 100 controls, and it was possible to discriminate between these and a range of benign glandular lesions. Expand
Karyometry of pseudostratified, metaplastic and dysplastic nasal epithelium by morphometry and stereology. 2. Automated image analysis (IBAS) of the basal layer of nickel workers.
TLDR
A mathematical model for the stereological analysis of parallel-oriented, spheroidal nuclei has been applied to the basal layers of respiratory, metaplastic and dysplastic nasal epithelia and adds some valuable objective criteria to those used in classical histopathological grading. Expand
Karyometry of pseudostratified, metaplastic and dysplastic nasal epithelium by morphometry and stereology. 1. A general model for automated image analysis of epithelia.
TLDR
A mathematical model is proposed to describe an aggregate of separate parallel anisotropic prolate spheroids of variable size and eccentricity suitable for the study of epithelial nuclei, and should be applicable to many other types of functionally or pathologically altered epithelia, particularly for cancer and precancer screenings. Expand
The Reliability of a Cytological Prediction of Cervical Adenocarcinoma In Situ
TLDR
This careful large study established that cytological prediction of adenocarcinoma in situ of the cervix is a very meaningful finding, with a false positive rate of only 2% i.e. 1 of 47 patients having adequate investigation; the other 46 patients having in situ or invasive carcinomas. Expand
A study to determine the underlying reason for abnormal glandular cytology and the formulation of a management protocol
TLDR
Of the patients presenting with post‐menopausal bleeding as well as having glandular dyskaryosis, 69% had a gynaecological malignancy and colposcopy and out‐patient endometrial sampling are recommended in all cases. Expand
Nuclear features of infiltrating urothelial carcinoma are distinguished from low-grade noninvasive papillary urothelial carcinoma by image analysis
TLDR
The results of the present study suggest that IA in combination with WSI may be a beneficial tool for evaluating morphometric characteristics and performing semi-quantitative analysis of IHC. Expand
Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma
TLDR
This study is the first to report that the low expression of emerin in cancer cell results in an oval shape of nuclei and nuclear enlargement in clinical samples, indicating the usefulness of WSI and IA for pathological specimen analysis. Expand
Karyometry by automated image analysis. Application to precancerous lesions.
TLDR
Karyometric studies on precancerous lesions may help to determine which lesions should be considered as possible premalignancies, and a new sphere unfolding model has been used on liver sections from Farber-protocol-treated rats. Expand