Endocarditis pathogen promotes vegetation formation by inducing intravascular neutrophil extracellular traps through activated platelets.

@article{Jung2015EndocarditisPP,
  title={Endocarditis pathogen promotes vegetation formation by inducing intravascular neutrophil extracellular traps through activated platelets.},
  author={Chiau-Jing Jung and Chiou-Yueh Yeh and R Y Hsu and C M Lee and C. T. Shun and J S Chia},
  journal={Circulation},
  year={2015},
  volume={131 6},
  pages={571-81}
}
BACKGROUND Endocarditis-inducing streptococci form multilayered biofilms in complex with aggregated platelets on injured heart valves, but the host factors that interconnect and entrap these bacteria-platelet aggregates to promote vegetation formation were unclear. METHODS AND RESULTS In a Streptococcus mutans endocarditis rat model, we identified layers of neutrophil extracellular traps interconnecting and entrapping bacteria-platelet aggregates inside vegetation that could be reduced… CONTINUE READING