Endocardial endothelium in the avascular frog heart: role for diffusion of NO in control of cardiac O2 consumption.

  title={Endocardial endothelium in the avascular frog heart: role for diffusion of NO in control of cardiac O2 consumption.},
  author={A M Adler and Harer Huang and Zipping Wang and J. A. Conetta and Ellen M. Leve{\'e} and Xiaoping Zhang and Thomas H. Hintze},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={287 1},
  • A. Adler, Harer Huang, T. Hintze
  • Published 1 July 2004
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
We investigated the role of nitric oxide (NO) in the control of myocardial O(2) consumption in the hearts of female Xenopus frogs, which lack a coronary vascular endothelium and in which the endocardial endothelium is the only source of NO to regulate cardiac myocyte function. Hence, frogs are an ideal model in which to explore the role of diffusion of NO from the endocardial endothelium (EE) without vascular endothelial or cardiac cell NO production. In Xenopus hearts we examined the… 

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