Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease.

@article{Gise2012EndocardialAE,
  title={Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease.},
  author={Alexander von Gise and William T. Pu},
  journal={Circulation research},
  year={2012},
  volume={110 12},
  pages={1628-45}
}
Epithelial to mesenchymal transition (EMT) converts epithelial cells to mobile and developmentally plastic mesenchymal cells. All cells in the heart arise from one or more EMTs. Endocardial and epicardial EMTs produce most of the noncardiomyocyte lineages of the mature heart. Endocardial EMT generates valve progenitor cells and is necessary for formation of the cardiac valves and for complete cardiac septation. Epicardial EMT is required for myocardial growth and coronary vessel formation, and… CONTINUE READING
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