Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage.

@article{Shouman2006EndocannabinoidsPP,
  title={Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage.},
  author={Basma Shouman and Romain H. Fontaine and Olivier Baud and Leslie Schwendimann and Matthias Keller and Michael Spedding and Vincent Lelievre and Pierre Gressens},
  journal={British journal of pharmacology},
  year={2006},
  volume={148 4},
  pages={442-51}
}
Brain lesions induced in newborn mice or rats by the glutamatergic agonists ibotenate (acting on NMDA and metabotropic receptors) or S-bromowillardiine (acting on AMPA-kainate receptors) mimic some aspects of white matter cysts and transcortical necrosis observed in human perinatal brain damage associated with cerebral palsy. Exogenous and endogenous cannabinoids have received increasing attention as potential neuroprotective agents in a number of neurodegenerative disorders of the adult. One… CONTINUE READING
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