Endocannabinoids link rapid, membrane-mediated corticosteroid actions to behavior.

@article{Denver2007EndocannabinoidsLR,
  title={Endocannabinoids link rapid, membrane-mediated corticosteroid actions to behavior.},
  author={Robert J. Denver},
  journal={Endocrinology},
  year={2007},
  volume={148 2},
  pages={
          490-2
        }
}
  • R. Denver
  • Published 1 February 2007
  • Biology
  • Endocrinology
The rapid actions of steroid hormones, although recognized for over half a century, until recently were largely overshadowed by the study of genomic actions mediated by nuclear hormone receptors. Many steroid hormones are now known to exert physiologically and behaviorally important actions within seconds to minutes, a time frame far too rapid to be mediated by genomic mechanisms. The recent isolation of several G protein-coupled receptors (GPCRs) that mediate the actions of sex steroids and 1… 
4 Citations

Figures from this paper

References

SHOWING 1-10 OF 32 REFERENCES

Minireview: rapid glucocorticoid signaling via membrane-associated receptors.

A brief review focused on multiple lines of evidence suggesting that rapid glucocorticoid actions are triggered by, or at least dependent on, membrane-associated G protein-coupled receptors and activation of downstream signaling cascades is provided.

Nongenomic effects of 1alpha,25-dihydroxyvitamin D(3).

Experimental evidence supports the hypothesis that biological effects of vitamin D can be generated both by a signal transduction mechanism involving a nuclear receptor that modulates gene transcription, and via a nongenomic receptor located in the plasma membrane which modulates a complex signaling system involving the rapid opening of Ca(2+) channels.

The emerging role of the endocannabinoid system in endocrine regulation and energy balance.

The ability of the endocannabinoid system to control appetite, food intake, and energy balance has recently received great attention, particularly in the light of the different modes of action underlying these functions.

Nongenomic Glucocorticoid Inhibition via Endocannabinoid Release in the Hypothalamus: A Fast Feedback Mechanism

A mechanism of rapid glucocorticoid feedback inhibition of hypothalamic hormone secretion via endocannabinoid release in the PVN is revealed and a link between the actions of glucoc Corticorticoids and cannabinoids in the hypothalamus that regulate stress and energy homeostasis is provided.

Rapid Central Corticosteroid Effects: Evidence for Membrane Glucocorticoid Receptors in the Brain1

A novel mechanism of rapid glucocorticoid inhibition of parvocellular neuroendocrine cells of the hypothalamic paraventricular nucleus (PVN) mediated by the retrograde release of endocannabinoids and suppression of synaptic glutamate release is observed.

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

Cloning of a cDNA from spotted seatrout ovaries encoding a protein that satisfies the following seven criteria for its designation as a steroid membrane receptor suggests the fish protein is a membrane progestin receptor mediating a “nonclassical” action of progestins to induce oocyte maturation in fish.

Guanyl nucleotides modulate binding to steroid receptors in neuronal membranes.

Results are consistent with the formation of a ternary complex of steroid, receptor, and guanine nucleotide-binding protein that is subject to regulation by guanyl nucleotides.

Endocannabinoids mediate the effects of acute stress and corticosterone on sex behavior.

Behavioral and electrophysiological data suggest that, in response to acute stress, elevated CORT concentration increases endocannabinoid signaling in the hindbrain and alters sexual behaviors by modulating the excitability of medullary circuits.

Mechanistic and Functional Studies of Rapid Corticosteroid Actions a

By studying the potent behavioral actions of corticosterone in an amphibian species, Taricha granulosa, this work has discovered receptor mechanisms for rapid steroid actions that are mediated through neuronal membranes, and is beginning to understand how corticosteroids modulate the neural substrates mediating reproductive behavior.

Activity‐dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus

Together, these findings demonstrate an activity‐dependent release of AEA and 2‐AG that leads to the suppression of glutamate release and that is capable of shaping spiking activity in magnocellular neurones.