Endocannabinoids and prostaglandins both contribute to GnRH neuron-GABAergic afferent local feedback circuits.

@article{Glanowska2011EndocannabinoidsAP,
  title={Endocannabinoids and prostaglandins both contribute to GnRH neuron-GABAergic afferent local feedback circuits.},
  author={Katarzyna M Glanowska and Suzanne M. Moenter},
  journal={Journal of neurophysiology},
  year={2011},
  volume={106 6},
  pages={3073-81}
}
Gonadotropin-releasing hormone (GnRH) neurons form the final common pathway for central control of fertility. Regulation of GnRH neurons by long-loop gonadal steroid feedback through steroid receptor-expressing afferents such as GABAergic neurons is well studied. Recently, local central feedback circuits regulating GnRH neurons were identified. GnRH neuronal depolarization induces short-term inhibition of their GABAergic afferents via a mechanism dependent on metabotropic glutamate receptor… CONTINUE READING

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