Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner.

@article{Amors2010EndocannabinoidsAC,
  title={Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner.},
  author={Irene Amor{\'o}s and Adriana Barana and Ricardo Caballero and Ricardo G{\'o}mez and Lourdes Osuna and M Pilar Lillo and Juan Luis Tamargo and Eva Delp{\'o}n},
  journal={Journal of molecular and cellular cardiology},
  year={2010},
  volume={48 1},
  pages={201-10}
}
Endocannabinoids are amides and esters of long chain fatty acids that can modulate ion channels through both receptor-dependent and receptor-independent effects. Nowadays, their effects on cardiac K(+) channels are unknown even when they can be synthesized within the heart. We have analyzed the direct effects of endocannabinoids, such as anandamide (AEA), 2-arachidonoylglycerol (2-AG), the endogenous lipid lysophosphatidylinositol, and cannabinoid analogues such as palmitoylethanolamide (PEA… CONTINUE READING

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Rotational dynamics of 1,6-diphenyl-1,3,5-hexatriene and derivatives from fluorescence depolarization

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