Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.

Abstract

Advanced liver cirrhosis is associated with hyperdynamic circulation consisting of systemic hypotension, decreased peripheral resistance, and cardiac dysfunction, termed cirrhotic cardiomyopathy. Previous studies have revealed the role of endocannabinoids and vascular CB(1) receptors in the development of generalized hypotension and mesenteric vasodilation… (More)

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@article{Btkai2007EndocannabinoidsAA, title={Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.}, author={S{\'a}ndor B{\'a}tkai and Partha Mukhopadhyay and Judith Harvey-White and Raouf Kechrid and Pal Pacher and George Kunos}, journal={American journal of physiology. Heart and circulatory physiology}, year={2007}, volume={293 3}, pages={H1689-95} }